CXXC4-AS1

Across TCGA pan-cancer cohorts, CXXC4-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated CXXC4-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CXXC4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CXXC4-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and PRAD show a favorable association.

KIRP, UCEC, and OV are the cancer types where CXXC4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.457	0.793	<.001	59	view →
UCEC	DFS	Tertile	IV	0.172	0.611	.001	42	view →
OV	OS	Tertile	All	0.795	0.860	.002	26	view →
PAAD	DFS	Quartile	All	0.691	0.426	<.001	23	view →
PRAD	DFS	Quartile	All	0.928	0.710	.002	22	view →
LUAD	DFS	Tertile	All	0.495	0.327	.008	17	view →
THCA	DFS	Quartile	All	0.613	0.857	.014	14	view →
SKCM	DFS	Tertile	IV	0.061	0.513	.016	12	view →
LIHC	DFS	Tertile	All	0.412	0.576	.019	9	view →
BRCA	DFS	Median	IV	0.874	0.607	.016	7	view →
DLBC	DFS	Tertile	All	0.574	0.935	.025	4	view →
KIRC	OS	Quartile	All	0.938	0.894	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

CXXC4-AS1–KIRP (OS)

Open the KIRP breakdown →