CXXC1

Across TCGA pan-cancer cohorts, CXXC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CXXC1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CXXC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CXXC1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where CXXC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.990	0.880	.004	21	view →
HNSC	OS	Quartile	All	0.140	1.000	.017	16	view →
PDAC	DFS	Tertile	II,III,IV	0.555	0.254	.007	13	view →
COAD	DFS	Median	II,III,IV	1.000	0.913	.036	12	view →
GBM	OS	Tertile	All	0.529	0.258	.007	11	view →
CCRCC	OS	Median	II,III,IV	0.851	1.000	.016	8	view →
UCEC	DFS	Median	II,III,IV	0.531	0.875	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CXXC1–LSCC (DFS)

Open the LSCC breakdown →