CXCR5

Across TCGA cell cohorts, CXCR5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,787 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CXCR5-associated GO terms across cancer lineages are Regulation of macrophage cytokine production, Negative regulation of T-helper 17 cell differentiation, and Gap junction assembly. Each is linked with CXCR5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CXCR5-to-partner and partner-to-CXCR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macrophage cytokine production grouped by CXCR5-low versus CXCR5-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR5→partner) and Y-score (partner→CXCR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of macrophage cytokine production →	+0.194	+2.493	<.001	<.001	3	4
BLOOD_Lymphoma	Negative regulation of T-helper 17 cell differentiation →	-0.110	-2.351	<.001	<.001	3	4
BLOOD_Leukemia	Gap junction assembly →	-0.457	-0.268	<.001	.009	3	4
BLOOD_Leukemia	Cardiac jelly development →	-0.376	-0.267	.008	.009	3	4
BLOOD_Lymphoma	Organic acid catabolic process →	-0.028	-2.187	.009	.001	3	3
BLOOD_Lymphoma	Regulation of gap junction assembly →	-0.806	-1.776	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,787 associations by consensus.

Regulation of macrophage cytokine production by CXCR5 expression — BLOOD_Lymphoma

Explore this box plot interactively →