CXCR4

Across TCGA pan-cancer cohorts, CXCR4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CXCR4 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher CXCR4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CXCR4 expression acts as an unfavorable survival marker.

DLBC, BLCA, and CESC are the cancer types where CXCR4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	All	0.102	0.959	<.001	33	view →
BLCA	OS	Median	All	0.069	0.688	<.001	33	view →
CESC	DFS	Median	II,III,IV	0.173	0.705	.028	6	view →
LUSC	OS	Median	All	0.340	0.663	.022	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	All	0.597	0.790	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CXCR4–DLBC (OS)

Open the DLBC breakdown →