Across TCGA patient cohorts, CXCR3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR3-associated genes across cancer lineages are Caspase-8, eEF2, and ERK2. Each is linked with CXCR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR3-to-partner and partner-to-CXCR3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR3→partner) and Y-score (partner→CXCR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.248	-2.115	.024	.019	3	2
UCEC	eEF2 →	+0.330	+2.115	.034	.019	3	1
UCEC	ERK2 →	+0.212	+2.807	.011	.003	3	1
UCEC	IGFBP2 →	-0.803	-3.321	.004	.010	3	1
UCEC	Ku80 →	+0.248	+2.128	.016	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.474	-2.459	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

CXCR3 survival (RNA) · tumor vs normal (RNA) · all CXCR3 data types