CXCR2

Across TCGA patient cohorts, CXCR2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR2-associated genes across cancer lineages are Shc_pY317, INPP4B, and Rictor_pT1135. Each is linked with CXCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR2-to-partner and partner-to-CXCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by CXCR2-low versus CXCR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR2→partner) and Y-score (partner→CXCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.136	-2.115	.040	.019	3	2
SKCM	INPP4B →	-0.188	-1.790	.017	.026	3	1
SKCM	Rictor_pT1135 →	+0.156	+3.000	.013	.034	3	1
UCEC	EGFR_pY1068 →	-0.280	-2.584	.010	.010	3	1
UCEC	MSH2 →	-0.341	-2.449	<.001	.019	3	1
UCEC	p62 Lck ligand →	+0.455	+3.179	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Shc_pY317 by CXCR2 expression — UCEC

Explore this box plot interactively →