CXCR2

Across TCGA pan-cancer cohorts, CXCR2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CXCR2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CXCR2 RNA is repressed in tumor relative to normal tissue. In most cancer types CXCR2 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where CXCR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXCR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−3.043	<.001	12	view →
KIRC	All	IV	+0.701	<.001	12	view →
LUAD	Male	All	−1.933	<.001	11	view →
LUSC	All	II,III,IV	−2.265	<.001	6	view →
BRCA	All	III,IV	−0.801	<.001	6	view →
LIHC	Female	All	−0.448	<.001	6	view →
COAD	All	II,III,IV	+0.507	.006	4	view →
STAD	All	II,III,IV	−1.168	.009	3	view →
BLCA	All	All	−1.100	.024	2	view →
PRAD	All	All	−0.986	<.001	2	view →
KICH	Female	II,III,IV	−0.372	.031	2	view →
READ	All	All	+1.267	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CXCR2–HNSC

Open the HNSC breakdown →