CXCR2

Across TCGA cell cohorts, CXCR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,393 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CXCR2-associated GO terms across cancer lineages are Negative regulation of RNA catabolic process, Regulation of mRNA catabolic process, and RNA stabilization. Each is linked with CXCR2 in more than 7 cancer types. Because this analysis shows association rather than direction, both CXCR2-to-partner and partner-to-CXCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA catabolic process grouped by CXCR2-low versus CXCR2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR2→partner) and Y-score (partner→CXCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of RNA catabolic process →	+0.052	+0.326	<.001	.004	3	8
BLOOD_Lymphoma	Regulation of mRNA catabolic process →	+0.040	+0.189	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	RNA stabilization →	+0.057	+0.550	<.001	<.001	3	6
BLOOD_Lymphoma	Cellular respiration →	+0.042	+0.179	.004	.001	3	5
BLOOD_Leukemia	CMP metabolic process →	-0.110	-1.149	<.001	.001	3	5
LUNG_SCLC	Negative regulation of catalytic activity →	+0.043	+0.091	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,393 associations by consensus.

Negative regulation of RNA catabolic process by CXCR2 expression — URINARY_TRACT

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