CXCR2

Across TCGA cell cohorts, CXCR2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CXCR2-associated genes across cancer lineages are CSN1S1, MSGN1, and TRARG1. Each is linked with CXCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR2-to-partner and partner-to-CXCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN1S1 grouped by CXCR2-low versus CXCR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR2→partner) and Y-score (partner→CXCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSN1S1 →	+0.059	+3.347	<.001	.005	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	TRARG1 →	+0.022	+3.345	<.001	.007	3	1
LARGE_INTESTINE	LRRC3C →	+0.283	+3.658	<.001	.005	3	1
LARGE_INTESTINE	RBMY1J →	+0.006	+4.022	<.001	.006	3	1
LUNG_SCLC	KRTAP12-4 →	+0.075	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

CSN1S1 by CXCR2 expression — LARGE_INTESTINE

Explore this box plot interactively →