CXCL8

Across TCGA patient cohorts, CXCL8 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL8-associated genes across cancer lineages are RDM1P1, RPS28P1, and MIR4752. Each is linked with CXCL8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXCL8-to-partner and partner-to-CXCL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RDM1P1 grouped by CXCL8-low versus CXCL8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL8→partner) and Y-score (partner→CXCL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RDM1P1 →	+0.129	+7.816	<.001	.008	3	3
BLCA	RPS28P1 →	+0.222	+5.329	.002	.006	3	2
UCEC	MIR4752 →	+0.225	+6.066	<.001	<.001	3	2
COAD	DUX4L19 →	+0.039	+7.741	<.001	.009	3	2
BLCA	RPL31P53 →	+0.147	+6.147	<.001	.002	3	2
BLCA	TVP23BP2 →	+0.072	+5.177	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

RDM1P1 by CXCL8 expression — SKCM

Explore this box plot interactively →