CXCL6

Across TCGA patient cohorts, CXCL6 protein abundance is significantly associated with the RNA expression of many other genes, with 3,436 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CXCL6-associated genes across cancer lineages are SPTLC2, PNN, and ZNF821. Each is linked with CXCL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL6-to-partner and partner-to-CXCL6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CXCL6 versus SPTLC2 in UCEC, with a Pearson correlation of -0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL6→partner) and Y-score (partner→CXCL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPTLC2 →	-0.578	-0.711	.001	.001	3	2
UCEC	PNN →	-0.977	-0.886	.006	.002	3	2
UCEC	ZNF821 →	-0.706	-0.766	.006	.001	3	2
UCEC	WDR48 →	-0.883	-0.773	<.001	.001	3	2
UCEC	SHQ1 →	-0.754	-0.701	<.001	.001	3	2
UCEC	TMEM42 →	-1.046	-0.983	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,436 associations by consensus.

CXCL6 vs SPTLC2 — UCEC

Explore this scatter interactively →