CXCL6

Across TCGA pan-cancer cohorts, CXCL6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CXCL6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CXCL6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CXCL6 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

COAD, STAD, and BRCA are the cancer types where CXCL6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXCL6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+1.570	<.001	8	view →
STAD	All	All	+1.944	<.001	7	view →
BRCA	All	III,IV	−0.740	<.001	6	view →
READ	All	All	+1.996	.013	5	view →
ESCA	All	All	+3.468	.002	4	view →
LUAD	Female	II,III,IV	+1.950	.001	4	view →
KIRP	Male	All	+1.907	.006	4	view →
KICH	Female	All	−1.890	.001	4	view →
CHOL	Female	All	+4.950	<.001	3	view →
BLCA	Male	All	+1.651	.009	3	view →
LUSC	All	All	+1.245	.002	3	view →
LIHC	All	All	−0.832	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CXCL6–COAD

Open the COAD breakdown →