CXCL6

Across TCGA patient cohorts, CXCL6 mutation is significantly associated with the RNA expression of many other genes, with 1,234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL6-associated genes across cancer lineages are PACSIN2, POLR3H, and GZMH. Each is linked with CXCL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL6-to-partner and partner-to-CXCL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PACSIN2 grouped by CXCL6-low versus CXCL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL6→partner) and Y-score (partner→CXCL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PACSIN2 →	+0.921	+3.459	<.001	.005	3	1
UCEC	POLR3H →	+0.430	+3.480	.007	.002	3	1
UCEC	GZMH →	+1.245	+3.480	.001	.002	3	1
UCEC	POLE2 →	+0.905	+3.343	<.001	.005	3	1
UCEC	VTI1B →	+0.593	+3.459	<.001	.005	3	1
UCEC	MTHFD1 →	+0.830	+3.387	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,234 associations by consensus.

PACSIN2 by CXCL6 expression — UCEC

Explore this box plot interactively →