CXCL6

Across TCGA patient cohorts, CXCL6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL6-associated genes across cancer lineages are GSK-3_pS9, JNK_pT183_Y185, and p38-MAPK_pT180_Y182. Each is linked with CXCL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL6-to-partner and partner-to-CXCL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by CXCL6-low versus CXCL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL6→partner) and Y-score (partner→CXCL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.575	-3.000	.009	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-3.156	.021	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.702	-3.156	.004	.020	3	1
UCEC	p62 Lck ligand →	+0.571	+3.009	.001	.019	3	1
UCEC	PCNA →	+0.329	+3.169	.005	.020	3	1
UCEC	MEK1 →	+0.648	+3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GSK-3_pS9 by CXCL6 expression — UCEC

Explore this box plot interactively →