CXCL6

Across TCGA cell cohorts, CXCL6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,167 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CXCL6-associated GO terms across cancer lineages are Leukemia inhibitory factor signaling pathway, Cellular component disassembly, and Regulation of cytokine-mediated signaling pathway. Each is linked with CXCL6 in more than 5 cancer types. Because this analysis shows association rather than direction, both CXCL6-to-partner and partner-to-CXCL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Leukemia inhibitory factor signaling pathway grouped by CXCL6-low versus CXCL6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL6→partner) and Y-score (partner→CXCL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Leukemia inhibitory factor signaling pathway →	+0.211	+2.156	<.001	.003	3	6
KIDNEY	Cellular component disassembly →	+0.029	+2.124	.005	.009	3	6
LUNG_NSCLC_LUAD	Regulation of cytokine-mediated signaling pathway →	+0.046	+1.146	<.001	.003	3	5
KIDNEY	Oocyte growth →	-0.148	-3.267	.002	.004	3	5
OESOPHAGUS	Atrial cardiac muscle tissue morphogenesis →	+1.195	+2.371	.003	.001	3	5
LUNG_NSCLC_LUAD	Canonical NF-kappaB signal transduction →	+0.060	+1.252	.006	.008	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,167 associations by consensus.

Leukemia inhibitory factor signaling pathway by CXCL6 expression — LIVER

Explore this box plot interactively →