CXCL5

Across TCGA patient cohorts, CXCL5 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL5-associated genes across cancer lineages are EGFR_pY1068, ERK2, and INPP4B. Each is linked with CXCL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL5-to-partner and partner-to-CXCL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CXCL5-low versus CXCL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL5→partner) and Y-score (partner→CXCL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.240	-2.321	.012	.033	3	1
UCEC	ERK2 →	+0.213	+1.678	.003	.023	3	1
UCEC	INPP4B →	-0.261	-2.321	.035	.033	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.354	-2.459	.040	.019	3	1
UCEC	p62 Lck ligand →	+0.364	+2.584	.003	.010	3	1
UCEC	Shc_pY317 →	-0.164	-2.087	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by CXCL5 expression — UCEC

Explore this box plot interactively →