CXCL5

Across TCGA pan-cancer cohorts, CXCL5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CXCL5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CXCL5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CXCL5 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

COAD, KIRC, and BRCA are the cancer types where CXCL5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXCL5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+3.312	<.001	11	view →
KIRC	Male	IV	+2.792	<.001	8	view →
BRCA	Female	All	−0.841	<.001	8	view →
KICH	All	II,III,IV	−0.363	<.001	8	view →
THCA	All	All	+0.611	<.001	7	view →
LUSC	Female	All	−3.502	<.001	6	view →
UCEC	All	All	+1.569	.002	6	view →
HNSC	All	III,IV	+1.488	.003	6	view →
READ	All	All	+4.536	.002	5	view →
BLCA	Male	All	+2.022	.003	5	view →
KIRP	All	All	+1.217	.002	5	view →
STAD	All	All	+2.105	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CXCL5–COAD

Open the COAD breakdown →