CXCL16

Across TCGA patient cohorts, CXCL16 mutation is significantly associated with the RNA expression of many other genes, with 528 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL16-associated genes across cancer lineages are RNU6-458P, RPS15AP3, and HMGN2P26. Each is linked with CXCL16 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXCL16-to-partner and partner-to-CXCL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-458P grouped by CXCL16-low versus CXCL16-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL16→partner) and Y-score (partner→CXCL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-458P →	+0.343	+7.954	<.001	.008	3	3
COAD	RPS15AP3 →	+0.227	+5.003	<.001	.004	3	2
COAD	HMGN2P26 →	+0.199	+4.516	<.001	.009	3	2
COAD	OSBPL9P5 →	+0.454	+6.734	<.001	<.001	3	2
UCEC	RNU6-206P →	+0.197	+4.075	<.001	.007	3	2
UCEC	HMGN2P11 →	+0.195	+2.307	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 528 associations by consensus.

RNU6-458P by CXCL16 expression — HNSC

Explore this box plot interactively →