CXCL10

Across TCGA patient cohorts, CXCL10 mutation is significantly associated with the RNA expression of many other genes, with 1,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL10-associated genes across cancer lineages are RNA5SP414, RNA5SP419, and ATF1P1. Each is linked with CXCL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL10-to-partner and partner-to-CXCL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by CXCL10-low versus CXCL10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL10→partner) and Y-score (partner→CXCL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.661	+3.255	<.001	<.001	3	2
UCEC	RNA5SP419 →	+0.813	+2.591	<.001	.004	3	2
COAD	ATF1P1 →	+0.228	+6.392	.003	.001	3	1
COAD	MRPS21P5 →	+0.349	+5.893	.002	.002	3	1
COAD	RPL35AP15 →	+0.249	+5.145	<.001	.007	3	1
LUAD	RNU4-66P →	+0.148	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,212 associations by consensus.

RNA5SP414 by CXCL10 expression — UCEC

Explore this box plot interactively →