CXCL10

Across TCGA pan-cancer cohorts, CXCL10 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CXCL10 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CXCL10 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CXCL10 expression acts as an unfavorable survival marker, although some lineages such as SKCM and OV show a favorable association.

SKCM, UVM, and KIRP are the cancer types where CXCL10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.406	0.264	<.001	152	view →
UVM	DFS	Median	All	0.392	0.790	<.001	103	view →
KIRP	DFS	Tertile	All	0.752	0.922	<.001	58	view →
OV	OS	Tertile	All	0.482	0.322	<.001	54	view →
LGG	OS	Median	All	0.737	0.882	<.001	50	view →
CESC	DFS	Quartile	II,III,IV	0.806	0.349	.007	42	view →
LAML	DFS	Quartile	All	0.378	0.690	<.001	36	view →
PAAD	OS	Quartile	All	0.312	0.608	<.001	30	view →
COAD	DFS	Quartile	All	0.803	0.541	.001	30	view →
HNSC	DFS	Quartile	All	0.712	0.523	.002	25	view →
THYM	DFS	Quartile	All	0.826	0.972	.011	23	view →
LIHC	DFS	Tertile	III,IV	0.342	0.064	.005	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CXCL10–SKCM (OS)

Open the SKCM breakdown →