CWH43

Across TCGA patient cohorts, CWH43 mutation is significantly associated with the RNA expression of many other genes, with 3,567 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CWH43-associated genes across cancer lineages are PGRMC2, RNA5SP412, and SUPV3L1. Each is linked with CWH43 in more than 3 cancer types. Because this analysis shows association rather than direction, both CWH43-to-partner and partner-to-CWH43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGRMC2 grouped by CWH43-low versus CWH43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWH43→partner) and Y-score (partner→CWH43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGRMC2 →	+0.387	+3.042	<.001	<.001	3	4
UCEC	RNA5SP412 →	+0.490	+1.677	<.001	.004	3	3
UCEC	SUPV3L1 →	+0.329	+1.788	.002	.001	3	3
UCEC	COASY →	+0.487	+3.879	<.001	<.001	3	3
UCEC	CCDC43 →	+0.475	+3.021	<.001	<.001	3	3
UCEC	GPATCH3 →	+0.318	+2.111	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,567 associations by consensus.

PGRMC2 by CWH43 expression — UCEC

Explore this box plot interactively →