CWC25

Across TCGA cell cohorts, CWC25 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CWC25-associated genes across cancer lineages are KRT33A, IAPP, and SLCO1C1. Each is linked with CWC25 in more than 1 cancer types. Because this analysis shows association rather than direction, both CWC25-to-partner and partner-to-CWC25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT33A grouped by CWC25-low versus CWC25-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWC25→partner) and Y-score (partner→CWC25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRT33A →	+0.027	+4.228	<.001	.006	3	1
LARGE_INTESTINE	IAPP →	+0.539	+3.906	<.001	.005	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.710	+3.772	<.001	.003	3	1
LARGE_INTESTINE	FAM205A →	+0.026	+3.614	<.001	.006	3	1
LARGE_INTESTINE	SHISAL1 →	+0.069	+3.658	.003	.005	2	1
LARGE_INTESTINE	KCNIP1 →	+0.048	+3.531	.002	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KRT33A by CWC25 expression — OVARY

Explore this box plot interactively →