CUTA

Across TCGA patient cohorts, CUTA mutation is significantly associated with the RNA expression of many other genes, with 313 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUTA-associated genes across cancer lineages are CACTIN, PLEKHH3, and NDOR1. Each is linked with CUTA in more than 1 cancer types. Because this analysis shows association rather than direction, both CUTA-to-partner and partner-to-CUTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACTIN grouped by CUTA-low versus CUTA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUTA→partner) and Y-score (partner→CUTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CACTIN →	+0.487	+3.202	.002	.009	3	2
SKCM	PLEKHH3 →	+0.608	+3.220	.003	.009	3	2
UCEC	NDOR1 →	+0.764	+3.332	<.001	.005	3	2
SKCM	PSG8-AS1 →	+0.115	+2.351	.005	.007	3	2
UCEC	AKIP1 →	+0.564	+3.346	.003	.005	3	1
UCEC	IRGQ →	+0.655	+3.364	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 313 associations by consensus.

CACTIN by CUTA expression — UCEC

Explore this box plot interactively →