CUTA

Across TCGA patient cohorts, CUTA mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUTA-associated genes across cancer lineages are Cyclin-B1, Di-Ras3, and ACC1. Each is linked with CUTA in more than 1 cancer types. Because this analysis shows association rather than direction, both CUTA-to-partner and partner-to-CUTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CUTA-low versus CUTA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUTA→partner) and Y-score (partner→CUTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.627	+3.012	.007	.018	3	2
UCEC	Di-Ras3 →	-0.182	-3.169	.025	.020	3	1
SKCM	ACC1 →	+0.436	+3.000	.014	.036	1	2
SKCM	Cyclin-D1 →	-0.346	-2.987	.006	.035	2	1
UCEC	VEGFR2 →	+0.373	+3.183	.022	.010	2	1
SKCM	eIF4E →	+0.251	+3.000	.013	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Cyclin-B1 by CUTA expression — SKCM

Explore this box plot interactively →