CUL9

Across TCGA pan-cancer cohorts, CUL9 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CUL9 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CUL9 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CUL9 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, KICH, and SCLC are the cancer types where CUL9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.911	0.423	.005	34	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SCLC	OS	Median	All	0.219	0.706	.011	6	view →
ESCA	DFS	Median	All	0.098	0.533	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CUL9–UCEC (DFS)

Open the UCEC breakdown →