CUL9

Across TCGA pan-cancer cohorts, CUL9 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CUL9’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CUL9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CUL9 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and CHOL are the cancer types where CUL9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CUL9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.479	<.001	9	view →
THCA	All	All	−0.257	<.001	7	view →
CHOL	Male	All	+1.980	<.001	5	view →
KICH	All	All	−0.636	<.001	5	view →
COAD	All	All	+0.239	.005	4	view →
STAD	Male	II,III,IV	+0.639	.037	1	view →
LUSC	All	All	+0.223	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CUL9–LIHC

Open the LIHC breakdown →