CUL9

Across TCGA pan-cancer cohorts, CUL9 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CUL9 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CUL9 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CUL9 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where CUL9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.862	0.585	.002	38	view →
PDAC	DFS	Median	III,IV	0.802	0.496	.003	13	view →
HNSC	OS	Median	All	0.449	1.000	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CUL9–LSCC (DFS)

Open the LSCC breakdown →