CUL9

Across TCGA patient cohorts, CUL9 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL9-associated genes across cancer lineages are ATM, c-Kit, and INPP4B. Each is linked with CUL9 in more than 4 cancer types. Because this analysis shows association rather than direction, both CUL9-to-partner and partner-to-CUL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CUL9-low versus CUL9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL9→partner) and Y-score (partner→CUL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.516	-1.700	<.001	<.001	3	5
SKCM	c-Kit →	-0.585	-1.925	.012	.004	3	5
BRCA	INPP4B →	-0.872	-3.000	.004	.038	3	4
STAD	GAPDH →	+0.310	+3.169	.037	.017	3	4
COAD	Caspase-7-cleavedD198 →	+0.937	+1.856	<.001	.004	3	4
BRCA	Bcl-2 →	-0.639	-3.000	.022	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

ATM by CUL9 expression — UCEC

Explore this box plot interactively →