CUL9

Across TCGA cell cohorts, CUL9 mutation is significantly associated with the RNA expression of many other genes, with 1,313 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUL9-associated genes across cancer lineages are GATAD2B, CHUK, and SCO2. Each is linked with CUL9 in more than 2 cancer types. Because this analysis shows association rather than direction, both CUL9-to-partner and partner-to-CUL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATAD2B grouped by CUL9-low versus CUL9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL9→partner) and Y-score (partner→CUL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GATAD2B →	+0.414	+1.458	.004	.009	3	3
LARGE_INTESTINE	CHUK →	+0.440	+1.458	.002	.009	3	3
LARGE_INTESTINE	SCO2 →	+0.436	+1.808	.009	.001	3	3
BLOOD_Myeloma	MTRNR2L5 →	+0.053	+4.807	<.001	.006	3	2
BLOOD_Lymphoma	MS4A2 →	+0.009	+4.643	<.001	.005	3	2
BREAST	GSTZ1 →	+1.073	+3.099	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,313 associations by consensus.

GATAD2B by CUL9 expression — LARGE_INTESTINE

Explore this box plot interactively →