CUL4B

Across TCGA patient cohorts, CUL4B mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL4B-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and ACC1. Each is linked with CUL4B in more than 1 cancer types. Because this analysis shows association rather than direction, both CUL4B-to-partner and partner-to-CUL4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CUL4B-low versus CUL4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL4B→partner) and Y-score (partner→CUL4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.200	+1.857	.008	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.085	-1.575	.021	.008	3	2
UCEC	ACC1 →	+0.294	+1.920	.006	.008	3	2
UCEC	VHL →	-0.600	-1.584	.002	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.583	+1.945	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.231	-2.087	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

FoxM1 by CUL4B expression — UCEC

Explore this box plot interactively →