CUL4A

Across TCGA pan-cancer cohorts, CUL4A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CUL4A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CUL4A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CUL4A expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

PDAC, LUAD, and UCEC are the cancer types where CUL4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.223	0.561	.002	26	view →
LUAD	DFS	Median	III,IV	0.941	0.575	.003	11	view →
UCEC	OS	Tertile	III,IV	1.000	0.300	.017	8	view →
CCRCC	OS	Median	III,IV	0.840	0.590	.032	3	view →
HNSC	DFS	Median	All	0.701	0.841	.017	2	view →
LSCC	OS	Median	II,III,IV	0.775	1.000	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CUL4A–PDAC (DFS)

Open the PDAC breakdown →