CUL4A

Across TCGA pan-cancer cohorts, CUL4A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CUL4A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CUL4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CUL4A is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, STAD, and KICH are the cancer types where CUL4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CUL4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+1.020	<.001	11	view →
STAD	Male	II,III,IV	+0.976	<.001	7	view →
KICH	Female	All	−0.792	<.001	7	view →
THCA	All	All	−0.293	<.001	7	view →
LIHC	All	All	+0.619	<.001	6	view →
BRCA	Female	II,III,IV	+0.355	<.001	6	view →
BLCA	All	All	+0.353	.003	6	view →
HNSC	All	II,III,IV	+0.419	.014	5	view →
READ	All	III,IV	+1.290	.005	4	view →
CHOL	All	All	+1.140	.001	4	view →
LUSC	All	All	+0.528	.002	3	view →
PAAD	Male	All	+0.314	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CUL4A–COAD

Open the COAD breakdown →