CUL4A

Across TCGA patient cohorts, CUL4A mutation is significantly associated with the RNA expression of many other genes, with 1,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL4A-associated genes across cancer lineages are RN7SKP60, C14orf177, and RNU7-53P. Each is linked with CUL4A in more than 2 cancer types. Because this analysis shows association rather than direction, both CUL4A-to-partner and partner-to-CUL4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP60 grouped by CUL4A-low versus CUL4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL4A→partner) and Y-score (partner→CUL4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP60 →	+0.116	+2.219	.002	.001	3	3
LUAD	C14orf177 →	+0.034	+5.888	<.001	.002	3	2
COAD	RNU7-53P →	+0.570	+5.136	<.001	.002	3	2
CESC	CASP1P1 →	+0.121	+4.559	<.001	.006	3	2
UCEC	MKRN2OS →	+0.542	+1.678	.002	.006	3	2
UCEC	VTRNA2-2P →	+0.232	+1.566	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,850 associations by consensus.

RN7SKP60 by CUL4A expression — UCEC

Explore this box plot interactively →