CUL4A

Across TCGA cell cohorts, CUL4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,547 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CUL4A-associated GO terms across cancer lineages are Ribosomal protein import into nucleus, Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, and Sister chromatid biorientation. Each is linked with CUL4A in more than 18 cancer types. Because this analysis shows association rather than direction, both CUL4A-to-partner and partner-to-CUL4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal protein import into nucleus grouped by CUL4A-low versus CUL4A-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL4A→partner) and Y-score (partner→CUL4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Ribosomal protein import into nucleus →	+0.113	+0.818	.002	.002	3	19
LUNG_SCLC	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.151	+1.469	<.001	<.001	3	18
LUNG_SCLC	Sister chromatid biorientation →	+0.166	+0.792	<.001	<.001	3	16
CNS	Positive regulation of mitotic sister chromatid separation →	+0.121	+0.808	<.001	<.001	3	12
LUNG_SCLC	Positive regulation of protein neddylation →	+0.148	+1.331	<.001	<.001	3	12
BONE	Double-strand break repair via classical nonhomologous end joining →	+0.066	+0.636	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,547 associations by consensus.

Ribosomal protein import into nucleus by CUL4A expression — OESOPHAGUS

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