CUL4A

Across TCGA cell cohorts, CUL4A mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUL4A-associated genes across cancer lineages are OPCML, MMP26, and KLF18. Each is linked with CUL4A in more than 1 cancer types. Because this analysis shows association rather than direction, both CUL4A-to-partner and partner-to-CUL4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPCML grouped by CUL4A-low versus CUL4A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL4A→partner) and Y-score (partner→CUL4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OPCML →	+0.006	+5.000	<.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.036	+4.415	<.001	<.001	3	1
LUNG_NSCLC_LUAD	AGXT2 →	+0.023	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	AADACL3 →	+0.223	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OPCML by CUL4A expression — PANCREAS

Explore this box plot interactively →