CUL2

Across TCGA cell cohorts, CUL2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CUL2-associated genes across cancer lineages are OR2A5, H3C11, and MEIKIN. Each is linked with CUL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUL2-to-partner and partner-to-CUL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A5 grouped by CUL2-low versus CUL2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL2→partner) and Y-score (partner→CUL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR2A5 →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	H3C11 →	+0.416	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	MEIKIN →	+0.155	+4.887	<.001	.009	3	1
BLOOD_Leukemia	GNGT1 →	+0.078	+3.551	<.001	.009	3	1
BLOOD_Leukemia	WNT3A →	+0.038	+4.169	.007	.003	3	1
BLOOD_Leukemia	TEX35 →	+0.221	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR2A5 by CUL2 expression — BLOOD_Myeloma

Explore this box plot interactively →