CUL1

Across TCGA pan-cancer cohorts, CUL1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CUL1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CUL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CUL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and HNSC are the cancer types where CUL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.960	0.669	.002	37	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.408	.018	16	view →
HNSC	DFS	Median	All	0.698	1.000	.020	13	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	13	view →
COAD	DFS	Tertile	IV	0.432	0.916	.026	12	view →
LUAD	OS	Median	II,III,IV	0.442	0.899	.015	9	view →
PDAC	OS	Median	II,III,IV	0.731	0.915	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CUL1–LSCC (OS)

Open the LSCC breakdown →