CUL1

Across TCGA patient cohorts, CUL1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and PRDX1. Each is linked with CUL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CUL1-to-partner and partner-to-CUL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CUL1-low versus CUL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL1→partner) and Y-score (partner→CUL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.349	-1.584	.021	.009	3	3
COAD	Caspase-7-cleavedD198 →	+1.282	+3.016	<.001	.018	3	3
BLCA	PRDX1 →	+0.250	+2.182	.022	.033	3	2
COAD	c-Myc →	-0.270	-3.161	.020	.019	3	2
UCEC	EGFR →	-0.138	-1.321	.009	.029	3	1
UCEC	FASN →	+0.293	+1.807	.026	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by CUL1 expression — UCEC

Explore this box plot interactively →