CUL1

Across TCGA cell cohorts, CUL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,965 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CUL1-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Nuclear transport, and Nucleocytoplasmic transport. Each is linked with CUL1 in more than 14 cancer types. Because this analysis shows association rather than direction, both CUL1-to-partner and partner-to-CUL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by CUL1-low versus CUL1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL1→partner) and Y-score (partner→CUL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.206	+0.922	<.001	.001	3	15
SOFT_TISSUE	Nuclear transport →	+0.081	+0.802	<.001	.001	3	15
SOFT_TISSUE	Nucleocytoplasmic transport →	+0.081	+0.802	<.001	.001	3	15
BREAST	DNA replication-dependent chromatin assembly →	+0.118	+1.110	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle G2/M phase transition →	+0.101	+0.924	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.131	+0.887	.006	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,965 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by CUL1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →