CUL1

Across TCGA cell cohorts, CUL1 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUL1-associated genes across cancer lineages are KAAG1, UCMA, and ERVV-1. Each is linked with CUL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CUL1-to-partner and partner-to-CUL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KAAG1 grouped by CUL1-low versus CUL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL1→partner) and Y-score (partner→CUL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KAAG1 →	+0.097	+3.855	<.001	.007	3	3
LARGE_INTESTINE	UCMA →	+0.014	+3.047	<.001	.001	3	2
BLOOD_Leukemia	ERVV-1 →	+0.495	+3.999	.001	.005	3	2
URINARY_TRACT	C1orf185 →	+0.097	+4.584	<.001	.002	3	1
LARGE_INTESTINE	SAMM50 →	+0.514	+3.212	.005	.006	3	1
LARGE_INTESTINE	TULP2 →	+0.099	+2.967	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

KAAG1 by CUL1 expression — BLOOD_Leukemia

Explore this box plot interactively →