CUL1

Across TCGA cell cohorts, CUL1 mutation is significantly associated with the mutation status of many other genes, with 2,527 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CUL1-associated genes across cancer lineages are EPN1, BTBD1, and PITPNM1. Each is linked with CUL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CUL1-to-partner and partner-to-CUL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPN1 grouped by CUL1-low versus CUL1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL1→partner) and Y-score (partner→CUL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EPN1 →	+5.339	+4.772	.004	.004	1	4
BLOOD_Leukemia	BTBD1 →	+5.635	+4.479	<.001	<.001	1	4
SKIN	PITPNM1 →	+4.239	+5.053	.007	.007	1	3
BLOOD_Leukemia	REPS2 →	+4.465	+4.465	<.001	<.001	1	3
SKIN	STRN4 →	+5.824	+5.824	.002	.002	1	3
URINARY_TRACT	PCDHA2 →	+3.672	+4.307	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,527 associations by consensus.

EPN1 by CUL1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →