CUEDC1

Across TCGA patient cohorts, CUEDC1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUEDC1-associated genes across cancer lineages are ERK2, STAT3_pY705, and JNK2. Each is linked with CUEDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUEDC1-to-partner and partner-to-CUEDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CUEDC1-low versus CUEDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUEDC1→partner) and Y-score (partner→CUEDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.179	+2.000	.039	.032	3	2
UCEC	STAT3_pY705 →	-0.517	-3.574	<.001	.002	3	2
UCEC	JNK2 →	+0.209	+2.000	.019	.032	3	1
UCEC	Notch1 →	+0.137	+2.700	.031	.006	3	1
UCEC	p27_pT198 →	+0.103	+3.807	.032	<.001	3	1
UCEC	Rad50 →	-0.302	-3.807	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ERK2 by CUEDC1 expression — UCEC

Explore this box plot interactively →