CUBN

Across TCGA pan-cancer cohorts, CUBN Mutation is linked to patient survival in 15 of 34 cancer types, making it a survival-associated CUBN data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CUBN Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CUBN expression acts as an unfavorable survival marker, although some lineages such as UCEC and OV show a favorable association.

UCEC, ACC, and OV are the cancer types where CUBN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.735	0.624	.004	36	view →
ACC	DFS	Median	All	0.120	0.772	<.001	30	view →
OV	DFS	Median	III,IV	0.776	0.150	.017	20	view →
HNSC	DFS	Median	II,III,IV	0.932	0.593	.011	18	view →
THYM	OS	Median	All	0.186	0.931	<.001	12	view →
PRAD	OS	Median	All	0.869	0.990	<.001	8	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	8	view →
SKCM	DFS	Median	II,III,IV	0.836	0.652	.019	7	view →
PAAD	DFS	Median	All	0.100	0.505	.004	6	view →
SARC	DFS	Median	All	0.200	0.634	.029	6	view →
KIRP	DFS	Median	IV	0.088	0.511	.002	6	view →
BLCA	OS	Median	III,IV	0.183	0.586	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

CUBN–UCEC (DFS)

Open the UCEC breakdown →