CUBN

Across TCGA pan-cancer cohorts, CUBN RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CUBN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CUBN RNA is repressed in tumor relative to normal tissue. In most cancer types CUBN is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where CUBN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CUBN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−4.450	<.001	10	view →
THCA	All	All	−0.440	<.001	9	view →
LIHC	All	All	+0.144	<.001	9	view →
KIRP	All	III,IV	−3.184	<.001	8	view →
LUSC	Male	III,IV	−0.562	<.001	8	view →
BRCA	All	III,IV	−0.793	<.001	6	view →
KIRC	All	All	+1.062	.004	4	view →
CHOL	Male	All	+0.799	<.001	3	view →
LUAD	Female	II,III,IV	−0.292	.026	3	view →
UCEC	All	All	−0.363	.023	2	view →
BLCA	All	All	−0.166	.034	2	view →
COAD	Female	III,IV	−0.202	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CUBN–KICH

Open the KICH breakdown →