CUBN

Across TCGA patient cohorts, CUBN protein abundance is significantly associated with the protein abundance of many other proteins, with 12,644 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible CUBN-associated proteins across cancer lineages are ARHGEF2_S932, ARHGEF37, and ARHGEF37_S251. Each is linked with CUBN in more than 1 cancer types. Because this analysis shows association rather than direction, both CUBN-to-partner and partner-to-CUBN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CUBN versus ARHGEF2_S932 in CCRCC, with a Pearson correlation of -0.44.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CUBN→partner) and Y-score (partner→CUBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARHGEF2_S932 →	-0.389	-0.458	<.001	<.001	3	1
CCRCC	ARHGEF37 →	+0.383	+0.420	<.001	<.001	3	1
CCRCC	ARHGEF37_S251 →	+0.988	+0.639	<.001	<.001	3	1
CCRCC	ARHGEF6_S225 →	-0.360	-0.362	<.001	<.001	3	1
CCRCC	ARHGEF7 →	+0.206	+0.414	<.001	<.001	3	1
CCRCC	ARHGEF7_S25 →	+0.604	+0.420	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,644 associations by consensus.

CUBN vs ARHGEF2_S932 — CCRCC

Explore this scatter interactively →