CUBN

Across TCGA patient cohorts, CUBN mutation is significantly associated with the RNA expression of many other genes, with 8,070 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUBN-associated genes across cancer lineages are PSMC3IP, POLE2, and OIP5. Each is linked with CUBN in more than 6 cancer types. Because this analysis shows association rather than direction, both CUBN-to-partner and partner-to-CUBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by CUBN-low versus CUBN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUBN→partner) and Y-score (partner→CUBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.537	+1.458	<.001	<.001	3	7
UCEC	POLE2 →	+0.369	+1.450	<.001	<.001	3	6
UCEC	OIP5 →	+0.692	+1.653	<.001	<.001	3	6
UCEC	NCAPH →	+0.422	+1.233	.001	.006	3	6
STAD	CKS2 →	+0.518	+1.869	.003	<.001	3	6
UCEC	PARP2 →	+0.359	+1.359	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,070 associations by consensus.

PSMC3IP by CUBN expression — UCEC

Explore this box plot interactively →