CUBN

Across TCGA cell cohorts, CUBN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,020 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CUBN-associated GO terms across cancer lineages are Negative regulation of alpha-beta T cell differentiation, Positive regulation of cell-substrate junction organization, and Organic cation transport. Each is linked with CUBN in more than 7 cancer types. Because this analysis shows association rather than direction, both CUBN-to-partner and partner-to-CUBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of alpha-beta T cell differentiation grouped by CUBN-low versus CUBN-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CUBN→partner) and Y-score (partner→CUBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of alpha-beta T cell differentiation →	+0.123	+0.188	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.165	+0.354	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Organic cation transport →	-0.067	-0.101	<.001	<.001	3	7
BONE	Regulation of establishment of cell polarity →	+0.104	+0.591	.002	.007	2	8
LUNG_NSCLC_LUSC	Positive regulation of lamellipodium assembly →	+0.106	+0.257	.002	.001	3	7
OESOPHAGUS	Positive regulation of focal adhesion assembly →	+0.175	+0.170	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,020 associations by consensus.

Negative regulation of alpha-beta T cell differentiation by CUBN expression — BREAST

Explore this box plot interactively →