CUBN

Across TCGA cell cohorts, CUBN mutation is significantly associated with the RNA expression of many other genes, with 1,394 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUBN-associated genes across cancer lineages are LYG1, CLDN8, and DEPDC5. Each is linked with CUBN in more than 3 cancer types. Because this analysis shows association rather than direction, both CUBN-to-partner and partner-to-CUBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by CUBN-low versus CUBN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUBN→partner) and Y-score (partner→CUBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.693	+1.405	.001	.005	3	4
BLOOD_Myeloma	CLDN8 →	+0.007	+4.000	<.001	.002	3	3
LARGE_INTESTINE	DEPDC5 →	+0.462	+1.584	.002	.005	3	3
LARGE_INTESTINE	NSMCE4A →	+0.483	+1.706	<.001	<.001	3	3
LARGE_INTESTINE	NUP88 →	+0.440	+1.667	.001	.006	3	3
LARGE_INTESTINE	MED31 →	+0.520	+2.115	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,394 associations by consensus.

LYG1 by CUBN expression — LARGE_INTESTINE

Explore this box plot interactively →