CTSZ

Across TCGA pan-cancer cohorts, CTSZ mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CTSZ data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CTSZ mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTSZ expression acts as an unfavorable survival marker.

COAD, LUAD, and OV are the cancer types where CTSZ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.565	1.000	.028	36	view →
LUAD	OS	Quartile	III,IV	0.373	0.789	.021	10	view →
OV	DFS	Median	All	0.674	1.000	.020	4	view →
PDAC	DFS	Median	III,IV	0.186	0.486	.033	3	view →
CCRCC	DFS	Tertile	III,IV	0.380	0.695	.017	3	view →
LSCC	OS	Quartile	All	0.725	1.000	.023	2	view →
HNSC	DFS	Quartile	II,III,IV	0.900	1.000	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CTSZ–COAD (DFS)

Open the COAD breakdown →