CTSZ

Across TCGA patient cohorts, CTSZ mutation is significantly associated with the RNA expression of many other genes, with 365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSZ-associated genes across cancer lineages are AP1S2P1, MIR3179-4, and RNA5SP411. Each is linked with CTSZ in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSZ-to-partner and partner-to-CTSZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1S2P1 grouped by CTSZ-low versus CTSZ-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSZ→partner) and Y-score (partner→CTSZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	AP1S2P1 →	+0.116	+6.309	.001	.001	3	2
LUAD	MIR3179-4 →	+0.543	+7.930	<.001	.008	3	2
UCEC	RNA5SP411 →	+1.074	+2.586	<.001	<.001	3	2
STAD	MIR3928 →	+0.781	+4.254	<.001	.008	3	2
COAD	TRDJ2 →	+0.945	+4.384	.002	.006	3	2
COAD	MRPL32P1 →	+0.290	+5.392	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 365 associations by consensus.

AP1S2P1 by CTSZ expression — LUSC

Explore this box plot interactively →